DIFFERENTIAL EFFECTS OF MYONEURAL BLOCKING DRUGS ON NEUROMUSCULAR TRANSMISSION IN INFANTS
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چکیده
منابع مشابه
Differential effects of myoneural blocking drugs on neuromuscular transmission in infants.
Equipotent, paralysing doses of pancuronium and tubocurarine were administered to 40 patients, aged from 1 day to 12 months, during nitrous oxide, oxygen and fentanyl anaesthesia. Neuromuscular activity was measured during onset and recovery from paralysis using train-of-four stimulation. At the same depression of the first stimulus of the train, the train-of-four ratio was decreased more durin...
متن کاملNeuromuscular blocking drugs in infants and children
Neuromuscular blocking drugs (NMBDs), are given to infants and children for anaesthesia to provide muscle relaxation, to reduce the quantity of anaesthetic agent required and to facilitate controlled ventilation. The effective use of NMBDs in paediatric practice requires a knowledge of certain fundamental differences in the responses of paediatric patients and adults to these drugs, and the phy...
متن کاملNeuromuscular blocking drugs in infants and children.
Neuromuscular blocking drugs are valuable adjuncts to the practice of pediatrics. Monitoring of drug effects is technically more difficult in the younger patient. Nevertheless, careful observation of drug effects will improve the usefulness of NMB and safeguard the patient from prolonged weakness. Although there are differences in neuromuscular function with age in the pediatric age range, the ...
متن کاملThe undesirable effects of neuromuscular blocking drugs.
Neuromuscular blocking drugs are designed to bind to the nicotinic receptor at the neuromuscular junction. However, they also interact with other acetylcholine receptors in the body. Binding to these receptors causes adverse effects that vary with the specificity for the cholinergic receptor in question. Moreover, all neuromuscular blocking drugs may cause hypersensitivity reactions. Often the ...
متن کاملAdverse effects of neuromuscular blocking drugs.
Neuromuscular blocking drugs are not as notorious for producing adverse reactions as the i.v. induction agents; nevertheless, to a varying degree they all produce unfavourable or harmful effects. The newer non-depolarizing neuromuscular blockers, atracurium and vecuronium, have been developed in an attempt to overcome the disadvantages of the earlier drugs, but although much more specific agent...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1984
ISSN: 0007-0912
DOI: 10.1093/bja/56.10.1095